massimo santoro malattia

In this context, the zebrafish (Danio rerio) is emerging as a valuable model system to learn about the metabolic routes critical for cellular homeostasis. News 5 … We will also highlight the potential of zebrafish for identifying antitumor angiogenesis drugs to block tumor development and progression. To pursue these molecular and pharmacological goals, researchers need to use animal models that facilitate the elucidation of tumor angiogenesis mechanisms and the testing of antiangiogenic therapies. Ecco le sue dichiarazioni. View Massimo Santoro’s profile on LinkedIn, the world's largest professional community. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. Primary cilia are microtubule-based organelles that protrude from the membrane of many cells, including neurons, osteoblasts, epithelial, and endothelial cells (ECs). We combine genetic and metabolic approaches coupled to advance imaging techniques to address specific biological questions and develop new therapeutic approaches. Moreover, we show that the CARD is required to suppress cell proliferation and migration. Such findings are providing an overview of the ROS biology relevant for endothelial cells in the context of normal and pathological angiogenic conditions. Here, the most recent methods and studies on cell metabolism are summarized, which support the overall value for the zebrafish model system not only to study metabolism but also metabolic disease states. Detecting and measuring the dynamic redox events that occur in vivo is a prerequisite for understanding the impact of oxidants and redox events in normal and pathological conditions. 14.30-17 (Ed.19) [email protected] Veneziani Bianca Maria PO Pat. Due to this, Aurora B remains trapped on chromatin in dividing cells and fails to translocate to the spindle midzone during cytokinesis. Here we show that the glycolytic enzyme pyruvate kinase M2 (PKM2) limits glucose oxidation, and maintains the growth and epigenetic state of ECs. Dai geni alla terapia: nuovi farmaci antitumorali. Massimo Mattia Santoro obtained is Master Diploma from University of Turin, Italy and his PhD in Molecular and Cellular Biology from the Open University, London, UK. Intravital imaging reveals that vessel growth in murine long bone involves the extension and anastomotic fusion of endothelial buds. We also identify zebrafish foxc1b as a cilia-dependent Notch-specific target that is required within endothelial cells to drive vMC recruitment. Thus, PDGFR-mediated mural cell recruitment mediates neurovascular interactions between the aorta and sympathetic precursors and promotes their noradrenergic differentiation. This protocol can be applied to different types of experimental settings, including tissue-specific metabolic analyses or dynamic metabolic changes that occur during vertebrate embryogenesis. Here, we use the zebrafish embryo to ask whether the DA is required for SN development. The protocol takes 5-7 d to complete, requiring minimal equipment and analytical expertise, and it represents a unique alternative to the existing ex vivo (e.g., cell lines) isotope-based metabolic methods. Here, we demonstrate that iSMCs arise from the lateral plate mesoderm (LPM) in a stepwise process. Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell (EC) polarity and vascular remodelling. SANTORO LAB Department of Biology, University of Padua, Italy Congenital or neonatal cardiomyopathies are commonly associated with a poor prognosis and have multiple etiologies. CILIA CONTROL VASCULAR MURAL CELL RECRUITMENT IN VERTEBRATES. Impaired blood flow leads to defective angiogenesis and osteogenesis, and downregulation of Notch signalling in endothelial cells. Abuso e maltrattamento nell’infanzia: implicazioni psicologiche per un conselling efficace. The Alk5-dependent induction of zeb1a and foxo1a is required for this morphogenetic process: zeb1a is responsible for driving LPM migration around the gut, whereas foxo1a regulates LPM predisposition to iSMC differentiation. Postganglionic sympathetic neurons (SNs) develop in close proximity to the dorsal aorta (DA) and innervate visceral smooth muscle targets. After sequential excitation at 405 nm and 488 nm the emission was collected between 500-520 nm every 2 min for an overall duration of 60 min. Thank you for your interest in our research. These probes detect hydrogen peroxide (H2O2) levels and glutathione redox potential (EGSH), both with high spatiotemporal resolution. Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs) oxidize only a minor fraction of glucose in mitochondria, a metabolic specialization that is poorly understood. Vascular mural cells (vMCs) are essential components of the vertebrate vascular system, controlling blood vessel maturation and homeostasis. We find that loss of PKM2 alters mitochondrial substrate utilization and impairs EC proliferation and migration in vivo. Last, we will discuss the potential therapeutic use of agents that directly or indirectly block metabolism. Join Facebook to connect with Massimo Santoro and others you may know. Learn more about our team and areas of study below. Primary cilia are microtubule-based organelles that protrude from the membrane of many cells, including neurons, osteoblasts, epithelial, and endothelial cells (ECs).1 In vertebrates, primary cilia function as a signaling platform by detecting extracellular stimuli and initiating intracellular signaling response.2 Besides having chemosensory function, primary cilia are best known as mechanosensors in some cells. Surprisingly, inhibition of eNOS prevents Ubiad1-dependent cardiovascular oxidative damage, suggesting a crucial role for this enzyme and nonmitochondrial CoQ10 in NO signaling. We identified two compound heterozygous variants in KIF20A; a maternal missense variant (c.544C>T: p.R182W) and a paternal frameshift mutation (c.1905delT: p.S635Tfs*15). While blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly understood. PPFIA1 DRIVES ACTIVE Α5Β1 INTEGRIN RECYCLING AND CONTROLS FIBRONECTIN FIBRILLOGENESIS AND VASCULAR MORPHOGENESIS. Protection against oxidative damage caused by excessive reactive oxygen species (ROS) by an antioxidant network is essential for the health of tissues, especially in the cardiovascular system. See the complete profile on LinkedIn and discover Massimo’s connections and jobs at similar companies. Precise morphogenetic and cellular mechanisms act in endothelial cells (ECs) to drive angiogenesis during growth and throughout adulthood. Cellular inhibitor of apoptosis (cIAP) proteins are E3 ligases that modulate diverse biological processes such as cell survival, proliferation, and migration. We also discuss recent work which provides a rationale for specific amino acid-restricted diets and its beneficial effects on vascular tissues, including extending the life span and preventing the development of a variety of diseases. Sia il 2017 che il 2018, infatti, sono stati caratterizzati da dolorose assenze. Genome-wide SNP typing and parametric linkage analysis was done in a recessive model to identify candidate regions. Tra questi anche suo genero, Massimo Santoro, scomparso a soli 52 anni stroncato da una grave malattia. Nel corso della sua carriera aveva lavorato a Quelli della notte con Renzo Arbore, passando poi ad altri programmi e facendosi apprezzare, anno dopo anno, per le sue doti da autore televisivo. Massimo aveva 52 anni e faceva parte dello staff di autori di Uno Mattina, noto programma televisivo.Proprio l’ex conduttrice di Forum ha diffuso, sabato scorso, la luttuosa notizia sul suo profilo Facebook: ‘Ciao, Massimo. Massimo Santoro si è spento lo scorso mese di novembre dopo aver lottato insieme a sua moglie in una lunga malattia. The laboratory of Massimo Santoro at University of Padua strives to understand blood vessels biology and cell metabolism in pathological angiogenesis and cancer progression. We hypothesized a novel autosomal recessive condition. Loss of UBIAD1 reduces the cytosolic pool of the antioxidant CoQ10 and leads to ROS-mediated lipid peroxidation in vascular cells. Here we show that, on Rab21-elicited internalization, FN-bound/active α5β1 is recycled to the EC surface. This procedure represents a valuable approach for researchers interested in studying the effect of gene manipulation on lipid metabolism in zebrafish and in understanding the genetic conditions that result in metabolism dysfunction. We identify a pathway, comprising the regulators of post-Golgi carrier formation PI4KB and AP-1A, the small GTPase Rab11B, the surface tyrosine phosphatase receptor PTPRF and its adaptor PPFIA1, which we propose acts as a funnel combining FN secretion and recycling of active α5β1 integrin from the trans-Golgi network (TGN) to the EC surface, thus allowing FN fibrillogenesis. Here, we identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). We provide evidence for the usefulness of these Tg lines for pharmacological compounds screening by addressing the blocking of pentose phosphate pathways (PPP) and glutathione synthesis, thus altering subcellular redox state in vivo. This is a crucial biological event in all vertebrates. During his career, he has been granted with the EMBO (2004) and HFSP (2005) long-term fellowships, the HFSP Career Developmental Award (2008), the Marie Curie Reintegration Grant (2010), the Odysseus-FWO Career Grant (2014), and, more recently, the ERC Consolidator Grant (2016). Rita Dalla Chiesa ricorda il genero Massimo Santoro, morto alcuni mesi fa. BLOOD FLOW CONTROLS BONE VASCULAR FUNCTION AND OSTEOGENESIS. This work reveals the metabolic and functional consequences of glucose oxidation in the endothelium, highlights the importance of PKM2 for endothelial growth and links metabolic dysfunction with autoimmune activation in ECs. We identified a novel autosomal recessive congenital restrictive cardiomyopathy, caused by a near complete loss-of-function of KIF20A. Generale 3037 Mar. It is envisioned that this small vertebrate system will help in the understanding of pathogenesis for numerous metabolic-related disorders in humans and in the identification of their therapeutic treatments. This finding further illustrates the relationship of cytokinesis and congenital cardiomyopathy. Grave lutto per Rita Dalla Chiesa dopo il dolore per Fabrizio Frizzi: qualche giorno fa, pare a causa di una Confocal time-lapse recordings were performed to follow the compartmentalized H2O2 and EGSH changes in the cardiovascular tissues of zebrafish embryos at 48 h post fertilization. Morto Massimo Santoro, genero di Rita Dalla Chiesa e autore di Uno Mattina A soli 52 anni è morto l’autore Rai, marito della figlia della Dalla Chiesa, Giulia Cirese. A novembre dello scorso anno è venuto a mancare Massimo Santoro, marito della figlia di Rita, Giulia Cirese. ©2018 BY SANTORO LAB. He worked as a post-doc fellow at University of California, San Francisco, USA, with Prof. Dr. Didier Stainier, where he became interested in cardiovascular development and endothelial homeostasis. Here, we have solved the structure of the caspase recruitment domain (CARD) of cIAP1 and identified that it is required for cIAP1 autoregulation. REAL-TIME QUANTIFICATION OF SUBCELLULAR H2O2 AND GLUTATHIONE REDOX POTENTIAL IN LIVING CARDIOVASCULAR TISSUES. In aged mice, skeletal blood flow and endothelial Notch activity are also reduced leading to decreased angiogenesis and osteogenesis, which is reverted by genetic reactivation of Notch. Si è infatti spento all’età di soli 52 anni Massimo Santoro, noto non solo per essere il genero di Rita Dalla Chiesa, ma anche per aver a lungo lavorato come autore di “Uno Mattina”, uno dei programmi di punta di casa Rai. We support the use of alternative anti-angiogenic therapy based on the manipulation of ROS signalling and metabolism to solve angiogenesis-related diseases. Recent advances arising from in vitro strategies for deriving mural cells from human pluripotent stem cells as well as from the zebrafish model will be discussed and the medical relevance of these discoveries will be highlighted. In 2017, he returned to Italy at University of Padua as Chair of Cell Biology at Department of Biology. Discrete molecular mechanisms have been associated with vMC development and differentiation. In 2008, he established his first independent laboratory at the University of Torino, opening the Molecular Biotechnology Center. Incontro con Massimo Santoro. Non sono ore facili per Rita Dalla Chiesa e per la sua famiglia, colpita da un grave lutto che coinvolge anche la Rai. Inhibition of platelet-derived growth factor receptor (PDGFR) signaling prevents VMC differentiation and also blocks NA differentiation of SN precursors. Translational blocking of KIF20A in a zebrafish model resulted in a cardiomyopathy phenotype. ZEBRAFISH AS A MODEL TO EXPLORE CELL METABOLISM, ANTIANGIOGENIC CANCER DRUG USING THE ZEBRAFISH MODEL. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryonic origin. ROS SIGNALING AND REDOX BIOLOGY IN ENDOTHELIAL CELLS. à morto lâ ex presidente delle Terme di Fiuggi, il professor Massimo Santoro. Massimo M. Santoro obtained is Master Diploma from University of Turin, Italy and his PhD in Molecular and Cellular Biology from the Open University, London, UK. Cell metabolism plays a key role in many essential biological processes. In this article we used transgenic zebrafish lines that express compartment-specific isoforms of the roGFP2-Orp1 and Grx1-roGFP2 biosensors, described in Panieri et al (2017) [1], to test the contribute of the pentose phosphate pathway and of the glutathione biosynthesis in the antioxidant capacity of myocardial and endothelial cells in vivo. We foresee the zebrafish model as an important system that can possibly complement well-established mouse models in cancer research to generate novel insights into the molecular mechanism of the tumor angiogenesis. à deceduto in un ospedale di Roma ieri pomeriggio. Combining pharmacological and genetic approaches, we show that TGFβ/Alk5 signaling drives the LPM ventral migration and commitment to an iSMC fate. Massimo Santoro, autore Tv, se ne è andato a 52 anni, era sposato con Giulia Cirese, figlia di Rita Dalla Chiesa, conosciuta nella redazione di Uno Mattina. Prima di affrontare il problema dell’abuso e del maltrattamento è opportuna una premessa su cosa vuol dire fare e come è stata fatta la storia dell’infanzia. AN EXCLUSIVE CELLULAR AND MOLECULAR NETWORK GOVERNS INTESTINAL SMOOTH MUSCLE CELL DIFFERENTIATION IN VERTEBRATES. The analysis and the interpretation of the data can be found in the associated article [1]. This protocol covers the loading of isotope precursor; extraction, preparation and quantification of the labeled lipid metabolites (e.g., the prenyl lipid CoQ10) by the means of HPLC-MS; and its analysis in zebrafish embryos. Using transgenic lines marking developing vMCs in zebrafish embryos, we find that vMCs are recruited by arterial-fated vessels and that the process is flow dependent. In this framework, PPFIA1 interacts with active α5β1 integrin and localizes close to EC adhesions where post-Golgi carriers are targeted. The sympathetic nervous system controls smooth muscle tone and heart rate in the cardiovascular system. We further show that TGFβ, zeb1a and foxo1a are tightly linked together by miR-145 In iSMC-committed cells, TGFβ induces the expression of miR-145, which in turn is able to downregulate zeb1a and foxo1a The absence of miR-145 results in only a slight reduction in the number of iSMCs, which still express mesenchymal genes but fail to contract. 14.30-17 (Ed.19) [email protected] SSD MED/04 CFU 5 Anno di corso III Semestre II Insegnamenti propedeutici previsti: Nessuno RISULTATI DI APPRENDIMENTO ATTESI Conoscenza e capacità di comprensione In particular, we describe how the mitochondria has a key role in regulating the interplay between redox homeostasis and metabolism within tumor cells. Exome sequencing analysis was done in unaffected and affected siblings. Further, CARD-mediated autoregulation is also necessary to maximally suppress caspase-8-dependent apoptosis and vascular tree degeneration in vivo. By generating novel transgenic (Tg) zebrafish lines that express compartment-specific Rogfp2-Orp1 and Grx1-Rogfp2 sensors we analyzed cytosolic, mitochondrial, and the nuclear redox state of endothelial cells and cardiomyocytes of living zebrafish embryos. Santoro era molto conosciuto nella città termale dove viveva. Massimo SANTORO. Together, our data uncover a cascade of molecular events that govern distinct morphogenetic steps during the emergence and differentiation of vertebrate iSMCs. This review outlines the metabolic-dependent mechanisms that tumors engage in when faced with oxidative stress conditions that are critical for cancer progression by producing redox cofactors. E3 ligases mediate the covalent attachment of ubiquitin to target proteins thereby enabling ubiquitin-dependent signaling. We show that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo. Besides glycolysis and fatty acid oxidation, endothelial cells rely on specific amino acids to proliferate, migrate, and survive. Our team has recently identified novel metabolic pathways that are crucial for tumor survival and cancer progression (more information available upon request). A stroncarlo un male incurabile. Massimo Mattia Santoro obtained is Master Diploma from University of Turin, Italy and his PhD in Molecular and Cellular Biology from the Open University, London, UK. We offer a dynamic work environment in a stimulating scientific surrounding with a young,enthusiastic, motivated team along the opportunity to contribute to high-impact projects. Whereas such oxidative stress conditions would be harmful to normal cells, they facilitate tumor growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. DATA ON METABOLIC-DEPENDENT ANTIOXIDANT RESPONSE IN THE CARDIOVASCULAR TISSUES OF LIVING ZEBRAFISH UNDER STRESS CONDITIONS. Mechanistically, we show that the NF-κB transcription factor RELB is responsive to PKM2 loss, limiting EC growth through the regulation of P53. The candidate must be a highly motivated researcher in a relevant discipline as well as having some experience in genetic, molecular, and/or cellular biology methods. LOSS OF PYRUVATE KINASE M2 LIMITS GROWTH AND TRIGGERS INNATE IMMUNE SIGNALING IN ENDOTHELIAL CELLS, NEW MODELS TO STUDY VASCULAR MURAL CELL EMBRYONIC ORIGIN: IMPLICATIONS IN VASCULAR DISEASES. To accomplish this goal his lab is taking advantage of innovative genetic and imaging technologies as well as new molecular and biochemical approaches in vertebrate models, such as zebrafish and mouse. Il saluto commovente di Uno Mattina a Massimo Santoro. ROLE OF AMINO ACID METABOLISM IN ANGIOGENESIS. Highly recommended as a CTO for startup-type enterprises. The transgenic zebrafish embryos were subdued to metabolic inhibition and subsequently challenged with H2O2 or the redox-cycling agent menadione to respectively mimic acute or chronic oxidative stress. Metabolism has a decisive role in many fundamental biological processes, including organism development and tissue homeostasis. The recent availability of novel technologies and organisms to model cell metabolism in vivo is expanding current knowledge of cell metabolism. We then consider the evidence that connects heterogeneities in smooth muscle cell and pericyte origins with disease. VASCULAR MURAL CELLS PROMOTE NORADRENERGIC DIFFERENTIATION OF EMBRYONIC SYMPATHETIC NEURONS. These findings identify UBIAD1 as a nonmitochondrial CoQ10-forming enzyme with specific cardiovascular protective function via the modulation of eNOS activity. FASHIONING BLOOD VESSELS BY ROS SIGNALLING AND METABOLISM. Formation and maturation of a functional vascular network is a process called angiogenesis. 1 person has recommended Massimo Join now to view View Massimo’s full profile See who you know in common Get introduced Contact Massimo directly Join to view full profile Get in touch with us for any questions or comments regarding our work and publications. The 405/488 nm ratio was normalized to the initial value obtained before oxidants addition and plotted over time. Targeting of molecular pathways involved in such tumor angiogenetic processes by using specific drugs or inhibitors is important for developing new anticancer therapies. Santoro MM, Beltrame M, Panakova D, Siekmann A, Tiso N, Venero Galanternik M, Jung HM, Weinstein B Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish FRONT CELL DEV BIOL However, mechanisms coordinating α5β1 integrin-mediated extracellular FN endocytosis and exocytosis of newly synthesized FN remain elusive. Rita Dalla Chiesa sta per tornare in tv dopo un periodo tremendo: la morte del genero e la malattia dell’ex marito Fabrizio Frizzi. The role of endothelial metabolism represents a crucial element governing the formation and the differentiation of blood vessels, termed angiogenesis. The purpose of this review is to provide an overview of redox mechanisms, sources and antioxidants that control signaling events in ECs. Rogfp2-based transgenic zebrafish lines represent valuable tools to characterize the impact of redox changes in living tissues and offer new opportunities for studying metabolic driven antioxidant response in biomedical research. Here we describe a protocol for fast and reliable (13)C-isotope-based in vivo metabolic profiling. We propose that blood flow and endothelial Notch signalling are key factors controlling ageing processes in the skeletal system. A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells and pericytes influences vessel properties, in particular the regional propensity to vascular diseases. These aspects are particularly relevant in cardiovascular tissues wherein alterations of the redox balance are associated with stroke, aging, and pharmacological intervention. Massimo is an inventive and organizational mind. Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M., Weinstein, B.M. Recent and new tools to investigate physiological ROS signaling will be also discussed. His lab is currently focused on studying how redox signaling, metabolism, and hemodynamic forces regulates endothelial homeostasis in development as well as during cancer progression. Intestinal smooth muscle cells (iSMCs) are a crucial component of the adult gastrointestinal tract and support intestinal differentiation, peristalsis and epithelial homeostasis during development. Such studies offer unique opportunities for designing new therapeutic strategies against metastasis and cancer spreading. The function of hemodynamic forces in controlling vMC recruitment is unclear. PROUDLY CREATED WITH WIX.COM, Department of Biology, University of Padua, Italy, LABORATORY OF ANGIOGENESIS AND REDOX METABOLISM, EXPLORING THE WONDERS OF BLOOD VESSELS AND CELLULAR METABOLISM. View the profiles of people named Massimo Santoro. Massimo’s goal is to expand the current vision of endothelial biology by identifying unforeseen metabolic and signaling mechanisms and used them to develop novel anti-angiogenesis therapies to treat cancer progression and diabetic conditions. In this review we discuss how ROS-mediated signalling events and distinctive metabolic pathways drive the biology of endothelial cells. Rita Dalla Chiesa in lacrime e dolorante: il lutto sempre vivo Generale 3758 Mar. In two siblings, a male and female, we identified an undescribed type of lethal congenital restrictive cardiomyopathy affecting the right ventricle. bar mutants show specific cardiovascular failure due to oxidative stress and ROS-mediated cellular damage. Human UBIAD1 is a nonmitochondrial prenyltransferase that synthesizes CoQ10 in the Golgi membrane compartment. The past few years have seen the zebrafish system emerge as a valid model organism to study developmental angiogenesis and, more recently, as an alternative vertebrate model for cancer research. The process of de novo vessel formation, called angiogenesis, is essential for tumor progression and spreading. Excellent communication skills in spoken and written English are required. In this review, we will discuss why the zebrafish model system has the advantage of being a vertebrate model equipped with easy and powerful transgenesis as well as imaging tools to investigate not only physiological angiogenesis but also tumor angiogenesis. The laboratory of Prof. Massimo Santoro offers a PhD position to study redox homeostasis and metabolism in cancer. NA differentiation is normal in cloche mutants that are devoid of endothelial cells but have VMCs. Angiogenesis, from the Greek blood vessels (angio) creation (genesis), is an important biological process that occurs both during health and disease. Tumor cells harbor genetic alterations that promote a continuous and elevated production of reactive oxygen species. In 2013 he was appointed VIB Group Leader and Full Professor at Vesalius Research Center at the University of Leuven, Belgium. 13C-ISOTOPE-BASED PROTOCOL FOR PRENYL LIPID METABOLIC ANALYSIS IN ZEBRAFISH EMBRYOS. In the linkage regions, we selected candidate genes that harbor two rare variants with predicted functional effects in the patients and for which the unaffected sibling is either heterozygous or homozygous reference. An ambiguous aspect of redox biology is how redox events occur in subcellular organelles including mitochondria, and nuclei. In summary, we have identified a hemodynamic-dependent mechanism in the developing vasculature that controls vMC recruitment. Massimo Santoro, morto all’età di 52 anni, era originario di Foggia ma viveva a Roma da molti anni. COMPOUND HETEROZYGOUS LOSS-OF-FUNCTION MUTATIONS IN KIF20A ARE ASSOCIATED WITH A NOVEL LETHAL CONGENITAL CARDIOMYOPATHY IN TWO SIBLINGS. Our laboratory focuses on the identification of novel molecular mechanisms and signaling pathways involved in formation of blood vessels in developmental and pathological conditions. Nelle ultime ore è morto Massimo Santoro, il genero di Rita Dalla Chiesa. Santoro Massimo* PO Pat. Then he moved as post-doctoral fellow to the University of California, San Francisco, USA, where he became interested in vascular development and in health and diseased angiogenesis. Often, the same mechanisms are responsible for the insurgence of vascular-associated pathologies. Massimo Santoro ha illustrato come le scoperte della biologia e della genetica hanno aperto nuove strade per la cura del cancro, delineando il ruolo dei geni nell’insorgenza dei tumori e le nuove possibilità di individuare strategie terapeutiche. In particolare, si occupa di una rara malattia oculare in cui questi processi … We demonstrate that the CARD inhibits activation of cIAP1's E3 activity by preventing RING dimerization, E2 binding, and E2 activation. Genetically-encoded Rogfp2 fluorescent probes have become powerful tools for real-time detection of redox events. Massimo has 6 jobs listed on their profile. The laboratory, located in the Department of Biology at the University of Padua, strives to understand blood vessels biology and cancer progression. 'Massimo ha lottato fino all'ultimo e Giulia con lui. ROS HOMEOSTASIS AND METABOLISM: A DANGEROUS LIASON IN CANCER CELLS. Indeed, recent studies indicate that endothelial primary cilia within blood vessels function as blood flow mechanosensors.3 In ECs, cilia use flow information to regulate their presence with more and longer cilia present in vascular areas with low shear stress and at vascular branch points or areas of high curvature.4 Clinical research studies have shown an augmented risk of intracranial aneurysm, as well as an increased risk of hemorrhage in patients with cilia deficiency.5 In agreement, recent work on both mouse and zebrafish models suggest a specific role for cilia in intracranial aneurysm and cerebral-vascular integrity.6,7 Overall, several indications support a role for cilia in cranial vessel stability. Aveva 70 anni. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. Nuovo lutto per la famiglia di Rita Dalla Chiesa. Drug discovery remains to be the main focus for biomedical research and represents the essence of antiangiogenesis cancer research. In particolare, si occupa di una rara malattia oculare in cui questi processi … Blocking vascular maturation inhibits VMC recruitment and blocks NA differentiation of SN precursors. Unraveling how E3 ligases are regulated is important because miscontrolled ubiquitylation can lead to disease. ©2018 BY SANTORO LAB. Furthermore, S-adenosylmethionine synthesis is impaired in the absence of PKM2, resulting in DNA hypomethylation, de-repression of endogenous retroviral elements (ERVs) and activation of antiviral innate immune signalling. We take advantage of tissue-specific CRISPR gene targeting to demonstrate that hemodynamic-dependent Notch activation and the ensuing arterial genetic program is driven by endothelial primary cilia.

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